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DIRECTOR - LAWRENCE I. GROSSMAN, Ph.D

Wayne State University/Perinatology Research Branch - Lawrence I. Grossman, Ph.D.Title

  • Henry L. Brasza Professor of Molecular Medicine and Genetics, Wayne State University
  • Director, Center for Molecular Medicine and Genetics

Education and Training

  • BS in chemistry, City College of New York
  • PhD in genetics and biochemistry, Albert Einstein College of Medicine, NY
  • Postdoctoral, California Institute of Technology, Pasadena, CA

Research Accomplishments

  • Characterized major mitochondrial stress regulator MNRR1/CHCHD2
  • First isolated and characterized isoforms of cytochrome oxidase subunit 4
  • Discovered the rapid evolution in primates of many electron transport chain genes

Research Interests

  • Structure and function of mitochondrial DNA
  • Regulation of mitochondrial function
  • Role of mitochondria in inflammation and disease

Selected Publications

  • Aras S, Maroun M-C, Song Y, Bandyopadhyay S, Stark A, Yang Z-Q, Long MP, Grossman LI, Fernández-Madrid F (2019). Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis. BMC Cancer (2019) 19:411.
  • Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S (2018). J Biol Chem, 293: 6517-6529.

SIDDHESH ARAS, MBBS Ph.D.

Wayne State University/Perinatology Research Branch - Siddhesh Aras, MBBS Ph.D.Title

  • Assistant Professor (Research), Center for Molecular Medicine and Genetics, Wayne State University School of Medicine. Full time status.

Education and Training

  • M.B.B.S, Grant Medical College, University of Mumbai, India (2001)
  • Residency, Clinical Microbiology, Grant Medical College, Sir JJ Group of Hospitals, Mumbai, India (2004)
  • Ph.D., Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, LA (2010)
  • Post-doctoral Fellow, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI (2014)

Research Accomplishments

  • Discovery of a novel mechanism of transcriptional activation by Epstein-Barr Nuclear Antigen 1.
  • Characterization of a novel HIF-independent oxygen responsive element activated under conditions of moderate experimental hypoxia.
  • Characterization of a novel cellular stress responsive protein, MNRR1 (Mitochondrial-Nuclear Retrograde Regulator 1).

Research Interests

  • Mitochondrial disease
  • Host cell bioenergetic regulation in response to viral infection
  • Role of mitochondria in neurodegeneration and cancer

Select Publications

  • Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI. MNRR1 (formerly CHCHD2) is a bi- organellar regulator of mitochondrial metabolism. Mitochondrion. 2015 Jan;20:43-51. PubMed PMID: 25315652.
  • Aras S, Singh G, Johnston K, Foster T, Aiyar A. Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009 Jun;5(6):e1000469. PubMed PMID: 19521517.
  • Aras S, Singh G, Johnston K, Foster T, Aiyar A. Zinc coordination is equired for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009 Jun;5(6):e1000469. PubMed PMID: 19521517.

NEERAJA PURANDARE, Ph.D.

Wayne State University/Perinatology Research Branch - Neeraja Parandare, Ph.D.Title

  • Postdoctoral Fellow, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Full-Time Status.

Education and Training

  • Integrated M.Sc. in Biotechnology, University of Pune, Maharashtra, India
  • Ph.D. in Molecular Biology and Genetics, Wayne State University, Detroit, USA

Research Accomplishments

  • Characterized distinct mechanisms for the functioning of CHCHD10, a protein associated with neurodegeneration, in two intracellular compartments- the nucleus and mitochondria
  • Identified a novel pathway for pathogenic effects of mutations in CHCHD10

Research Interests

  • Mitochondrial biology
  • Metabolic adaptation in response to cellular stress
  • Immune signaling

Select Publications

  • Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S. The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction. J Biol Chem. 2018 Mar 14. pii: jbc.RA117.001073. doi: 10.1074/jbc.RA117.001073.
  • Aras S, Arrabi H, Purandare N, Huttemann, M, Kamholz J, Zuchner S, Grossman LI. Abl2 Kinase Phosphorylates Bi-organellar Regulator MNRR1 in Mitochondria, Stimulating Respiration. BBA Mol Cell Res. 2016 doi: 10.1016/j.bbamcr.2016.11.029.