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OBJECTIVES

  • To study the mechanisms whereby damage-associated molecular patterns (DAMPs) induce sterile intra-amniotic inflammation and spontaneous preterm labor and birth.
  • To investigate the function of leukocytes in the amniotic cavity of women with intra-amniotic infection/inflammation.
  • To mechanistically elucidate the homeostatic role of innate immune cells in late gestation in order to develop strategies to prevent inflammation-induced preterm labor.
  • To mechanistically elucidate the roles of effector and regulatory T cells in spontaneous preterm labor.