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IMPORTANT POINTS & DISCOVERIES

  • Molecular and culture-based studies of amniotic fluid from pregnancies complicated by preterm labor showed that the amniotic cavity harbors DNA from a great diversity of microbes than previously suspected, including non-cultivable and difficult to cultivate bacteria.
  • The use of rapid MMP-8 and IL-6 bedside tests to detect intra-amniotic inflammation and to identify women at risk for imminent preterm delivery.
  • Determination of the prevalence and clinical significance of amniotic fluid "sludge" in women with spontaneous preterm labor with intact membranes and in asymptomatic women at high risk of spontaneous preterm delivery.
  • First description of the identification of a microbial biofilm in amniotic fluid from pregnancies with intra-amniotic infection associated with amniotic fluid "sludge".  
  • Analysis of the proteomic profiling of amniotic fluid from spontaneous preterm labor using two-dimensional liquid separation and mass spectrometry, as well as the use of a novel computational method to analyze mass spectrometric profiling of amniotic fluid to identify women with preterm labor and intra-amniotic inflammatory complications.
  • Longitudinal study of angiogenic and anti-angiogenic factors in uncomplicated pregnancy and pregnancy destined to develop preeclampsia or small-for-gestational age fetus
  • The value of concentrations of angiogenic and anti-angiogenic factors in maternal plasma in the first and mid trimesters to identify women destined to develop preeclampsia.