Maternal stress is a well-established risk factor for preterm birth and has been associated with adverse neonatal outcomes in the first and subsequent generations, including increased susceptibility to disease and lasting immunological changes.
Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity.
The aim of this work was to develop a spreadsheet-based estimated fetal weight (EFW) percentile calculator and corresponding R software package to encompass six fetal growth standards.
This represents the largest amniotic fluid transcriptomics study in normal pregnancy, reporting for the first time that single-cell genomic signatures can be tracked in the amniotic fluid and display complex patterns of expression during gestation.
Here, we report low biomass background correction (LBBC), a bioinformatics noise filtering tool informed by the uniformity of the coverage of microbial genomes and the batch variation in the absolute abundance of microbial cfDNA.