Overlooked Immune Cells Trigger Preterm Labor

New Insights Could Help Reduce Premature Births BY BRANDON LEVY Any baby born less than 37 weeks after conception is considered premature, but not all premature births have the same root cause. In a new study, IRP researchers have detailed how a …

Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics

Theis KR1, Romero R2, Winters AD3, Greenberg JM3, Gomez-Lopez N4, Alhousseini A5, Bieda J6, Maymon E7, Pacora P6, Fettweis JM8, Buck GA9, Jefferson KK10, Strauss JF 3rd11, Erez O12, Hassan SS13. The human placenta has been traditionally viewed as sterile, and microbial invasion of this organ has been associated with adverse pregnancy outcomes. Yet, …

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes.

Theis KR1, Romero R2, Winters AD3, Greenberg JM3, Gomez-Lopez N4, Alhousseini A5, Bieda J6, Maymon E7, Pacora P6, Fettweis JM8, Buck GA9, Jefferson KK10, Strauss JF 3rd11, Erez O12, Hassan SS13. Intra-amniotic infection is present in 10% of patients with an episode of preterm labor, and is a risk factor for impending preterm delivery …

Cross-hemispheric functional connectivity in the human fetal brain

Thomason ME1, Dassanayake MT, Shen S, Katkuri Y, Alexis M, Anderson AL, Yeo L, Mody S, Hernandez-Andrade E, Hassan SS, Studholme C, Jeong JW, Romero R. Wayne State University and the Perinatology Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of …