Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes

Galaz J, Romero R, Slutsky R, Xu Y, Motomura K, Para R, Pacora P, Panaitescu B, Hsu CD, Kacerovsky M, Gomez-Lopez N.
J Perinat Med. 2020 Feb 14. pii: /j/jpme.ahead-of-print/jpm-2019-0395/jpm-2019-0395.xml. doi: 10.1515/jpm-2019-0395. [Epub ahead of print]
PMID: 32083453

Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity. However, the cellular immune responses in amniotic fluid of women with pPROM have not been investigated. Women with pPROM and a positive amniotic fluid culture exhibit a more severe cellular immune response than those with a negative culture, which is associated with well-known markers of intra-amniotic inflammation.

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