Offer Erez, M.D.

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Academic Affiliations
  • Adjunct Professor, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University School of Medicine and the Perinatology Research Branch, NICHD/NIH/DHHS
  • Professor, Faculty of Health Sciences and Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer-Sheva, Israel
Education and Training
  • M.D. – School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev
    Beer-Sheva, Israel
  • Fellowship – Research Associate, Perinatology Research Branch, NICHD/NIH/DHHS
    Hutzel Women’s Hospital, Detroit Medical Center, Wayne State University School of Medicine
  • Residency – Obstetrics and Gynecology Department "B", Soroka University Medical Center, Beer-Sheva, Israel
  • Internship – Kaplan Medical Center, Rehovot, Israel
Research Accomplishments
  • Published the DIC score in pregnancy and established an international registry on DIC in pregnancy
  • Generated the definition of non-overt DIC in pregnancy
  • Authored and co-authored more than 250 reports and case studies in the field of obstetrics and gynecology
  • Edited a book on preterm birth
  • Identified the association between early-onset preeclampsia and increased risk of cerebral palsy
  • Identified the safety of trail of labor after cesarean section in women with Mullerian anomalies
  • Identified the role of tissue factor in the great obstetrical syndromes
Awards and Recognitions
  • Most cited paper of the British Journal of Obstetrics and Gynecology in 2019
  • "Preterm parturition syndrome"2018 Award of Leadership Excellence– Perinatology Research Branch, NICHD/NIH/DHHS
  • Best Clinical Department of the Soroka University Medical Center in 2015
  • 2014 Distinguished Reviewer – Thrombosis Research
  • Recognized among the Top 5% of Reviewers in 2011 for the American Journal of Obstetrics and Gynecology
  • 2008 Award of Academic Excellence – Perinatology Research Branch
  • The Frederick P. Zuspan Award for Clinical Research presented at the XVI World Congress of the International Society for the Study of Hypertension in Pregnancy, Washington, D.C., September 2008.
  • 2001 Fourth Prize for Excellence presented at the Annual Quality Assessment Convention of Kupat Holim Clalit.
  • 2000 Second Prize for Excellence presented at the Joint Meeting of the American Institute of Ultrasound in Medicine and the Israeli Society for Ultrasound in Obstetrics and Gynecology.
    Research Interests
    • DIC in pregnancy
    • Obstetrical hemorrhage
    • Critical care in pregnancy
    • Preeclampsia
    • Placental vascular disease
    Select Publications
    • Spolter F, Kloog I, Dorman M, Novack L, Erez O, Raz R. Prenatal exposure to ambient air temperature and risk of early delivery. Environ Int. 2020 Sep; 142:105824. PMID: 32603968
    • Rabinovich A, Abdul-Kadir R, Thachil J, Iba T, Othman M, Erez O. Reply to "Errors in the diagnosis for DIC due to a statistical misunderstanding". J Thromb Haemost. 2020 Jul; 18:1792-1793. PMID: 32619348
    • Shashar S, Kloog I, Erez O, Shtein A, Yitshak-Sade M, Sarov B, Novack L. Temperature and preeclampsia: Epidemiological evidence that perturbation in maternal heat homeostasis affects pregnancy outcome. PLoS One. 2020 May 18; 15:e0232877. PMID: 32421729
    • Jaiman S, Romero R, Pacora P, Jung E, Bhatti G, Yeo L, Kim YM, Kim B, Kim CJ, Kim JS, Qureshi F, Jacques SM, Erez O, Gomez-Lopez N, Hsu CD. Disorders of placental villous maturation in fetal death. J Perinat Med. 2020 Apr 1. Online ahead of print. PMID: 32238609
    • Kabiri D, Romero R, Gudicha DW, Hernandez-Andrade E, Pacora P, Benshalom-Tirosh N, Tirosh D, Yeo L, Erez O, Hassan SS, Tarca AL. Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards. Ultrasound Obstet Gynecol. 2020 Feb; 55:177-188. PMID: 31006913
    • Szilagyi A, Gelencser Z, Romero R, Xu Y, Kiraly P, Demeter A, Palhalmi J, Gyorffy BA, Juhasz K, Hupuczi P, Kekesi KA, Meinhardt G, Papp Z, Draghici S, Erez O, Tarca AL, Knöfler M, Than NG. Placenta-specific genes, their regulation during villous trophoblast differentiation and dysregulation in preterm preeclampsia. Int J Mol Sci. 2020 Jan 17; 21:628. PMID: 31963593
    • Alhousseini A, Romero R, Benshalom-Tirosh N, Gudicha D, Pacora P, Tirosh D, Kabiri D, Yeo L, Thachil J, Hsu CD, Hassan SS, Erez O. Nonovert disseminated intravascular coagulation (DIC) in pregnancy: a new scoring system for the identification of patients at risk for obstetrical hemorrhage requiring blood product transfusion. J Matern Fetal Neonatal Med. 2020 Feb 3:1-16. Online ahead of print. PMID: 31931643
    • Romero R, Gomez-Lopez, N, Erez O, Gudicha D, Than N G, Benshalom-Tirosh N, Pacora P, Hsu, CD, Chaiworapongsa, T, Hassan SS, Tarca A. Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study. J Matern Fetal Neonatal Med. 2020 Jan 3:1-12. Online ahead of print. PMID: 31900005
    • Pikovsky O, Arafat M, Ovadia H, Sharoni Y, Al-Athamen K, Kanengisser-Pines B, Keren-Politansky A, Levi I, Erez O, Parvari R, Rabinovich A. Congenital thrombotic thrombocytopenic purpura in a large cohort of patients carrying a novel mutation in ADAMTS13 gene. Thromb Res. 2020 Jan; 185:167-170. PMID: 31837614
    • Panaitescu B, Romero R, Gomez-Lopez N, Pacora P, Erez O, Vadillo-Ortega F, Yeo L, Hassan SS, Hsu CD. ELABELA plasma concentrations are increased in women with late-onset preeclampsia.
    • J Matern Fetal Neonatal Med. 2020 Jan; 33:5-15. PMID: 29890874
    • Romero R, Gomez-Lopez N, Winters AD, Jung E, Shaman M, Bieda J, Panaitescu B, Pacora P, Erez O, Greenberg JM, Ahmad MM, Hsu CD, Theis KR. Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study. J Perinat Med. 2019 Nov 26; 47:915-931. PMID: 31693497
    • Handelman SK, Romero R, Pacora P, Ingram B, Maymon E, Chaiworapongsa T, Hassan SS, Erez O. The plasma metabolome of women in early pregnancy differs from that of non-pregnant women. PLoS One. 2019 Nov 14; 14:e0224682. PMID: 31726468
    • Rattila S, Dunk CE, Im M, Grichenko O, Zhou Y, Cohen M, Yanez‐Mo M, Blois SM, Yamada KM, Erez O, Gomez‐Lopez N, Lye SJ, Hinz B, Romero R, Dveksler G. Interaction of pregnancy‐specific glycoprotein 1 with integrin Α5β1 is a modulator of extravillous trophoblast functions. Cells. 2019 Oct 31; 8:1369. PMID: 31683744
    • Besser L, Sabag-Shaviv L, Yitshak-Sade M, Mastrolia SA, Landau D, Beer-Weisel R, Klaitman V, Benshalom-Tirosh N, Mazor M, Erez O. Medically indicated late preterm delivery and its impact on perinatal morbidity and mortality: a retrospective population-based cohort study. J Matern Fetal Neonatal Med. 2019 Oct; 32:3278-3287. PMID: 29621920.
    • Rabinovich A, Abdul-Kadir R, Thachil J, Iba T, Othman M, Erez O. DIC in obstetrics: Diagnostic score, highlights in management, and international registry-communication from the DIC and Women's Health SSCs of the International Society of Thrombosis and Haemostasis. J Thromb Haemost. 2019 Sep; 17:1562-1566. PMID: 31218838
    • Othman M, Santamaría Ortiz A, Cerdá M, Erez O, Minford A, Obeng-Tuudah D, Blondon M, Bistervels I, Middeldorp S, Abdul-Kadir R. Thrombosis and hemostasis health in pregnancy: Registries from the International Society on Thrombosis and Haemostasis. Res Pract Thromb Haemost. 2019 Aug 1; 3:607-614. PMID: 31624780
    • Hizkiyahu R, Rabinovich A, Thachil J, Sheiner E, Shaked G, Sebbag G, Maymon E, Erez O. Modified ISTH pregnancy-specific DIC score in parturients with liver rupture: population-based case series. J Matern Fetal Neonatal Med. 2019 Aug; 32:2517-2523. PMID: 29466901.
    • Brzezinski-Sinai NA, Stavsky M, Rafaeli-Yehudai T, Yitshak-Sade M, Brzezinski-Sinai I, Imterat M, Mastrolia SA, Erez O. Induction of labor in cases of late preterm isolated oligohydramnios: is it justified? J Matern Fetal Neonatal Med. 2019 Jul; 32:2271-2279. PMID: 29343146
    • Docheva N, Romero R, Chaemsaithong P, Tarca AL, Bhatti G, Pacora P, Panaitescu B, Chaiyasit N, Chaiworapongsa T, Maymon E, Hassan SS, Erez O. The profiles of soluble adhesion molecules in the "great obstetrical syndromes". J Matern Fetal Neonatal Med. 2019 Jul; 32:2113-2136. PMID: 29320948
    • Tarca AL, Romero R, Benshalom-Tirosh N, Than NG, Gudicha DW, Done B, Pacora P, Chaiworapongsa T, Panaitescu B, Tirosh D, Gomez-Lopez N, Draghici S, Hassan SS, Erez O. The prediction of early preeclampsia: Results from a longitudinal proteomics study. PLoS One. 2019 Jun 4; 14:e0217273. PMID: 31163045
    • Panaitescu B, Romero R, Gomez-Lopez N, Xu Y, Leng Y, Maymon E, Pacora P, Erez O, Yeo L, Hassan SS, Hsu CD. In vivo evidence of inflammasome activation during spontaneous labor at term. J Matern Fetal Neonatal Med. 2019 Jun; 32:1978-1991. PMID: 29295667
    • Rabinovich A, Holtzman K, Shoham-Vardi I, Mazor M, Erez O. Oligohydramnios is an independent risk factor for perinatal morbidity among women with pre-eclampsia who delivered preterm. J Matern Fetal Neonatal Med. 2019 Jun; 32:1776-1782. PMID: 29237307
    • Balogh A, Toth E, Romero R, Parej K, Csala D, Szenasi NL, Hajdu I, Juhasz K, Kovacs AF, Meiri H, Hupuczi P, Tarca AL, Hassan SS, Erez O, Zavodszky P, Matko J, Papp Z, Rossi SW, Hahn S, Pallinger E, Than NG. Placental galectins are key players in regulating the maternal adaptive immune response. Front Immunol. 2019 Jun; 10:1240. PMID:31275299
    • Pacora P, Romero R, Erez O, Maymon E, Panaitescu B, Kusanovic JP, Tarca AL, Hsu CD, Hassan SS. The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species. J Matern Fetal Neonatal Med. 2019 May; 32:1703-1720. PMID: 29226760
    • Gomez-Lopez N, Romero R, Maymon E, Kusanovic JP, Panaitescu B, Miller D, Pacora P, Tarca AL, Motomura K, Erez O, Jung E, Hassan SS, Hsu CD. Clinical chorioamnionitis at term IX: in vivo evidence of intra-amniotic inflammasome activation. J Perinat Med. 2019 Apr 24; 47:276-287. PMID: 30412466
    • Theis KR, Romero R, Winters AD, Greenberg JM, Gomez-Lopez N, Alhousseini A, Bieda J, Maymon E, Pacora P, Fettweis JM, Buck GA, Jefferson KK, Strauss JF 3rd, Erez O, Hassan SS. Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics. Am J Obstet Gynecol. 2019 Mar; 220:267.e1-267.e39. PMID: 30832984.
    • Pacora P, Romero R, Jaiman S, Erez O, Bhatti G, Panaitescu B, Benshalom-Tirosh N, Jung EJ, Hsu CD, Hassan SS, Yeo L, Kadar N. Mechanisms of death in structurally normal stillbirths. J Perinat Med. 2019 Feb 25; 47:222-240. PMID: 30231013
    • Tarca AL, Romero R, Xu Z, Gomez-Lopez N, Erez O, Hsu CD, Hassan SS, Carey VJ. Targeted expression profiling by RNA-Seq improves detection of cellular dynamics during pregnancy and identifies a role for T cells in term parturition. Sci Rep. 2019 Jan 29; 9:848. PMID: 30696862
    • Karaszi K, Szabo S, Juhasz K, Kiraly P, Kocsis-Deak B, Hargitai B, Krenacs T, Hupuczi P, Erez O, Papp Z, Kovalszky I, Than NG. Increased placental expression of placental protein 5 (PP5) / tissue factor pathway inhibitor-2 (TFPI-2) in women with preeclampsia and HELLP syndrome: relevance to impaired trophoblast invasion? Placenta. 2019 Jan; 76:30-39. PMID: 30803712
    Book Editorship
    • Preterm Birth. 1st edition, Erez O (editor), InTech, 2013.

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