Fetal T cell activation in the amniotic cavity during preterm labor: a potential mechanism for a subset of idiopathic preterm birth

Fetal immune cells can be detected in the amniotic cavity even in the absence of inflammation. Therefore, PRB researchers proposed studying amniotic fluid immune cells as a window into the fetal immune system in-utero.

The team reported for the first time that the fetal T cells undergo premature activation in women with spontaneous preterm labor and birth in the absence of intra-amniotic inflammation. Such findings provide evidence suggesting that fetal T cell activation is implicated in the pathogenesis of idiopathic preterm labor and birth.

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