Academic Affiliations
- Assistant Professor (Research)
Wayne State University
Department of Obstetrics and Gynecology
Education
- Ph.D. in Molecular Biomedicine with an emphasis in Maternal-Fetal Immunobiology, The Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexico
- M.Sc. in Biomedicine and Molecular Biotechnology. National Polytechnic Institute, National School of Biological Sciences & National Institute of Perinatology, Mexico City, Mexico
- B.Sc. in Chemistry, Bacteriology and Parasitology. National Polytechnic Institute, National School of Biological Sciences. Mexico City. Mexico
Awards and Recognitions
- 2019 The American Society for Reproductive Immunology (poster), Grand Rapids, Michigan – 2nd Place
- 2016 The American Association of Immunologists Travel Grant. International Congress of Immunology (ICI), Melbourne, Australia
- 2016 International Society of Immunology for Reproduction Travel Grant, 13th Congress of the International Society of Immunology for Reproduction, Eurfurt, Germany
- 2014 Best Master’s Degree Thesis in Biomedical Research, First Place, National Institutes of Health and General Hospitals of High Specialty, Mexico City, Mexico
- 2010 Basic Research Award, 61st Mexican Congress of Gynecology and Obstetrics, Mexico – 2nd place
Research Interests
- The role of T cells and their cytokines in the pathophysiology of preterm birth
- The maternal-fetal immune interactions in normal pregnancy and its complications
- The evaluation of biomarkers for prediction of the Great Obstetrical Syndromes
Select Publications
- Arenas-Hernandez M, Romero R, Xu Y, Panaitescu B, Garcia-Flores V, Miller D, Ahn H, Done B, Hassan SS, Hsu CD, Tarca AL, Sanchez-Torres C, Gomez-Lopez N. Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone. J Immunol. 2019 May 1;202(9):2585-2608. doi: 10.4049/jimmunol.1801350. Epub 2019 Mar 27. PMID: 30918041; PMCID: PMC6570421.
- Gomez-Lopez N, Arenas-Hernandez M, Romero R, Miller D, Garcia-Flores V, Leng Y, Xu Y, Galaz J, Hassan SS, Hsu CD, Tse H, Sanchez-Torres C, Done B, Tarca AL. Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes. Cell Rep. 2020 Jul 7;32(1):107874. doi: 10.1016/j.celrep.2020.107874. PMID: 32640239; PMCID: PMC7396155.
- Arenas-Hernandez M, Sanchez-Rodriguez EN, Mial TN, Robertson SA, Gomez-Lopez. Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface. J Vis Exp. 2015 May 21;(99):e52866. doi: 10.3791/52866. PMID: 26067389; PMCID: PMC4542974.
- Arenas-Hernandez M, Romero R, St Louis D, Hassan SS, Kaye EB, Gomez-Lopez N. An imbalance between innate and adaptive immune cells at the maternal-fetal interface occurs prior to endotoxin-induced preterm birth. Cell Mol Immunol. 2016 Jul;13(4):462-73. doi: 10.1038/cmi.2015.22. Epub 2015 Apr 6. PMID: 25849119; PMCID: PMC4947814.
- Arenas-Hernandez M, Gomez-Lopez N, Garcia-Flores V, Rangel-Escareño C, Alvarez-Salas LM, Martinez-Acuña N, Vazquez-Perez JA, Vega-Sanchez R. Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term. Genes Immun. 2019 Jan;20(1):56-68. doi: 10.1038/s41435-017-0010-z. Epub 2018 Jan 24. PMID: 29362510; PMCID: PMC6358585.
- Gomez-Lopez N, Romero R, Xu Y, Miller D, Arenas-Hernandez M, Garcia-Flores V, Panaitescu B, Galaz J, Hsu CD, Para R, Berry SM. Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth. J Immunol. 2019 Oct 1;203(7):1793-1807. doi: 10.4049/jimmunol.1900621. Epub 2019 Sep 6. PMID: 31492740; PMCID: PMC6799993.
- Gomez-Lopez N, Romero R, Arenas-Hernandez M, Ahn H, Panaitescu B, Vadillo-Ortega F, Sanchez-Torres C, Salisbury KS, Hassan SS. In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth. Am J Reprod Immunol. 2016 Nov;76(5):386-390. doi: 10.1111/aji.12562. Epub 2016 Sep 23. PMID: 27658719; PMCID: PMC5167555.
- St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, Milovic T, Xu Z, Bhatti G, Mi QS, Drewlo S, Tarca AL, Hassan SS, Gomez-Lopez N. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol. 2016 Feb 1;196(3):1044-59. doi: 10.4049/jimmunol.1501962. Epub 2016 Jan 6. PMID: 26740111; PMCID: PMC4724534.