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2020 NEWS

Maternal stress is a well-established risk factor for preterm birth and has been associated with adverse neonatal outcomes in the first and subsequent generations, including increased susceptibility to disease and lasting immunological changes.

Preterm birth is the leading cause of perinatal morbidity and mortality. Preterm prelabor rupture of membranes (pPROM) occurs in 30% of preterm births; thus, this complication is a major contributor to maternal and neonatal morbidity.

The aim of this work was to develop a spreadsheet-based estimated fetal weight (EFW) percentile calculator and corresponding R software package to encompass six fetal growth standards.

This represents the largest amniotic fluid transcriptomics study in normal pregnancy, reporting for the first time that single-cell genomic signatures can be tracked in the amniotic fluid and display complex patterns of expression during gestation.

Separating the signal from the noise in metagenomic cell-free DNA sequencing

Here, we report low biomass background correction (LBBC), a bioinformatics noise filtering tool informed by the uniformity of the coverage of microbial genomes and the batch variation in the absolute abundance of microbial cfDNA.

The placement of a cervical pessary did not reduce the risk of preterm birth (<37, <34, <32, and <28 weeks of gestation) or adverse perinatal outcomes in women with: a) Singleton gestations and a cervical length ≤25 mm; b) Unselected twin gestations; c) Twin gestations and a cervical length <38 mm; or d) twin gestations and a cervical length ≤25 mm.

The aim of this study was to investigate whether a model combining the measurement of sFas and Elabela in the maternal circulation may serve as a clinical biomarker for early- and/or late-onset preeclampsia more effectively than measures of each biomarker individually.

Using an allogeneic mouse model in which a paternal green fluorescent protein (GFP) can be tracked in the fetuses, we established that cell-free fetal DNA (Egfp) concentrations were higher in late gestation compared to...

Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor

The main aim of this study was to test whether the protein abundance internal to and on the surface of extracellular vesicles changes in the presence of sterile intra-amniotic inflammation and proven intra-amniotic infection in women with...

The aim of this study was to determine whether, among women with preterm PROM, there is an association between detectable microorganisms in amniotic fluid and intra-amniotic inflammation, and whether intra-amniotic inflammasome activation correlates with microbial burden.


2019 NEWS

More than 135 million births occur each year; yet, the molecular underpinnings of human parturition in gestational tissues, and in particular the placenta, are still poorly understood.

Functional Connectome of the Fetal Brain

Large-scale functional connectome formation and reorganization is apparent in the second trimester of pregnancy, making it a crucial and vulnerable time window in connectome development.

The primary reason that an ascending pathway is viewed as most common is that the microorganisms most often detected in the amniotic fluid are those that are typical inhabitants of the vagina.

In comparison to the non-pregnant state, the first trimester of pregnancy is characterized by systemic adaptation of the mother. The extent to which these adaptive processes are reflected in the maternal blood metabolome is not well characterized.

Overlooked Immune Cells Trigger Preterm Labor

Any baby born less than 37 weeks after conception is considered premature, but not all premature births have the same root cause. In a new study, IRP researchers have detailed how a particular component of the immune system can trigger premature labor, which could help doctors prevent more preterm births.

Predicting premature birth: How to interpret immune markers of early labor

Every Monday, Jennifer Degl leads a group through the halls of the neonatal intensive care unit at Maria Fareri Children’s Hospital in Valhalla, N.Y. The volunteers offer support to the parents of babies born early and struggling to survive.

The assessment of fetal growth disorders requires a standard. Current nomograms for the assessment of fetal growth in African American women have been derived either from neonatal (rather than fetal) biometry data or have not been customized for maternal ethnicity, weight, height, and parity and fetal sex.

Does the endometrial cavity have a molecular microbial signature?

Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination.

The human placenta has been traditionally viewed as sterile, and microbial invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent studies that utilized sequencing techniques reported that the human placenta at term contains a unique microbiota.

Intra-amniotic infection is present in 10% of patients with an episode of preterm labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality. Intra-amniotic inflammation is often associated with intra-amniotic infection, but is sometimes present in the absence of detectable microorganisms.


2018 AND PRIOR NEWS

Investigators (Dr. Lami Yeo and Dr. Roberto Romero) of the National Institute of Child Health and Human Development's Perinatology Research Branch housed at Wayne State University and the Detroit Medical Center have recently developed...

For years, Detroit has been known to have a high rate of premature birth and infant mortality.