Maternal-Fetal Immunobiology

About the Program

  • Conduct translational and clinical research on the immunological pathways that lead to obstetrical disorders, with the goals of improving the understanding of the mechanisms of disease and of developing methods for the early diagnosis, monitoring, treatment, and prevention of pregnancy complications, with an emphasis on preterm birth.
  • Train post-graduate and graduate-level professionals in maternal-fetal immunology.

Summary Videos of Our Research

Objectives

  • To study the mechanisms whereby damage-associated molecular patterns (DAMPs) induce sterile intra-amniotic inflammation and spontaneous preterm labor and birth.
  • To mechanistically elucidate the homeostatic role of innate immune cells in the third period of pregnancy in order to develop novel strategies to prevent inflammation-induced preterm labor and birth.
  • To mechanistically elucidate the roles of effector and regulatory T cells in the pathophysiology of spontaneous preterm labor.
  • To investigate host immune interactions during pregnancy.
  • To study the immunobiology of immune cells in the amniotic cavity and maternal-fetal interface.
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Selected Publications

Distinguished Faculty

 

DIRECTOR
Nardhy Gomez-Lopez, MSc, Ph.D.

Director of the Perinatal Immunobiology Unit, Wayne State University Perinatal Initiative in support of the Perinatology Research Branch, NICHD/NIH/DHHS,

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