Perinatal Epidemiology, Systematic Reviews and Meta-analyses

About the Program

The Perinatal Epidemiology, Systematic Reviews and Meta-analyses Unit compiles and critically appraises existing evidence on:

  • The efficacy and safety of preventive and therapeutic interventions in obstetrics and maternal-fetal medicine, mainly those related with the “great obstetrical syndromes”, through the use of formal methods for systematic reviews and meta-analyses of randomized controlled trials and non-randomized studies
  • The accuracy of tests proposed for the prediction and diagnosis of obstetrical and maternal-fetal conditions through the use of formal methods for systematic reviews and meta-analyses of predictive/diagnostic studies
  • The effect of exposure(s) on obstetrical and maternal-fetal conditions through the use of formal methods for systematic reviews and meta-analyses of observational studies

Our aim is to translate evidence from systematic reviews and meta-analyses into clinical practice.

Objectives

  • To conduct systematic reviews and meta-analyses of randomized controlled trials, non-randomized studies, predictive and diagnostic test studies, and observational studies in the field of obstetrics and maternal-fetal medicine

Research Focus

  • Risk factors, prediction, prevention, diagnosis, and treatment of these conditions:
    • preterm delivery
    • fetal growth restriction
    • preeclampsia
    • fetal death
    • premature rupture of membranes and clinical chorioamnionitis

Highlights

  • Reported that the use of vaginal progesterone prevents preterm birth and improves perinatal outcomes in both singleton and twin gestations with a mid-trimester sonographic short cervix
  • Demonstrated that kangaroo mother care, defined as skin-to-skin contact between a mother and her newborn, frequent and exclusive or nearly exclusive breastfeeding, and early discharge from the hospital reduces morbidity and mortality in preterm and low-birthweight infants
  • Showed that magnesium sulfate administration to women at risk of preterm delivery before 34 weeks of gestation reduces the risk of cerebral palsy in their offspring

Selected Publications

  • Romero R, Conde-Agudelo A, Da Fonseca E, O'Brien JM, Cetingoz E, Creasy GW, et al. Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol 2018;218:161-80.
  • Romero R, Conde-Agudelo A, El-Refaie W, Rode L, Brizot ML, Cetingoz E, et al. Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data. Ultrasound Obstet Gynecol 2017;49:303-14.
  • Conde-Agudelo A, Díaz-Rossello JL. Kangaroo mother care to reduce morbidity and mortality in low birthweight infants. Cochrane Database Syst Rev 2016;8:CD002771.
  • Conde-Agudelo A, Romero R. Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks' gestation: a systematic review and metaanalysis. Am J Obstet Gynecol 2009;200:595-609.

Distinguished Faculty

 

DIRECTOR
Agustin Conde-Agudelo, MD, MPH, PhD

Head of the Unit of Systematic Reviews and Meta-Analyses in Obstetrics and Maternal-Fetal Medicine

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