Section Head, Placental Pathology Unit, Wayne State University Perinatal Initiative in support of the Perinatology Research Branch, NICHD/NIH/DHHS
Assistant Professor, Department of Obstetrics and Gynecology, Wayne State University School of Medicine
Assistant Professor, Department of Pathology, Wayne State University School of Medicine
Chairman Perinatal Pathology Committee, Stillbirth Society of India
Education and Training
MBBS Degree – Assam Medical College, Dibrugarh University, Assam, INDIA
Internship training and Junior Residency – Safdarjung Hospital, New Delhi, INDIA
MD and Residency: M.D. Pathology (Tutor cum Resident), Kasturba Medical College, Manipal University, Manipal, Karnataka, INDIA
Associateship Royal College of Pathology (UK)
Diplomateship Royal College of Pathology (UK)
Provided evidence that delayed villous maturation is associated with evidence of chronic fetal hypoxia and with a higher concentration of amniotic fluid erythropoietin than in controls without delayed villous maturation.
Demonstrated that placentas of women with fetal death were forty-four times more likely to present disorders of villous maturation compared to placentas of those with normal pregnancy outcome suggesting that the burden of placental disorders of villous maturation lesions is substantial.
Described disorders of villous maturation to be present in nearly one-third of the cases of spontaneous preterm labor and showed that the association between delayed villous maturation and acute placental inflammation in spontaneous preterm labor as observed is more than serendipitous and has adaptive and survival value.
Demonstrated hypoxia, secondary to placental dysfunction, to be the mechanism of death in the majority of fetal deaths among structurally normal fetuses with ninety-one percent of hypoxic fetal deaths sustaining brain, myocardial or both brain and myocardial injuries in utero.
Discovered a placental tumor “Chorangioendothelioma” and provided its nomenclature.
Described the first case from the Indian subcontinent of Mardini–Nyhan association (LACHT syndrome: unilateral complete/partial lung agenesis, congenital cardiac defects, and ipsilateral thumb anomalies) with intrauterine fetal demise.
Described the first case series from the Indian subcontinent of congenital apple peel jejunal atresia with helical umbilical cord ulcers afflicting all female offspring in consecutive pregnancies in a single nonconsanguineous family with all pregnancies culminating in perinatal death.
Described capricious behavior of endophytic squamous cell carcinoma of the cervix with extensive lymphovascular invasion of the corpus uteri, both the fallopian tubes and bilateral ovarian deposits without involving either the endometrium or the tubal mucosa.
Determined that any vessel/band that courses from the peritoneal surface of the umbilicus towards the portal vein, is most likely representing persistent left vitelline vein; and that all cases of umbilical vein varix should be evaluated for possible thrombosis in the umbilical and portal veins and an abnormal course since a communication with portal vein would suggest persistent left vitelline vein and possible agenesis of ductus venosus. Failure to prenatally detect these anomalies may result in fetal hypoxemia, portal hypertension, thrombosis, and fetal death.
Demonstrated that Pallister-Hall syndrome (PHS), a pleiotropic autosomal-dominant malformation syndrome rarely presenting with genitourinary malformations such as hydrometrocolpos and/or vaginal atresia may succumb during pregnancy due to congenital corticotrophin deficiency in the pituitary gland.
Development of the human placenta
Disorders of placental villous maturation
Placental contribution to fetal death
Placental causes of preterm labor and preterm PROM
Jaiman S, Romero R, Pacora P, Erez O, Jung EJ, Tarca AL, Bhatti G, Yeo L, Kim YMK, Kim CJ, Kim JS, Qureshi F, Jacques SM, Gomez-Lopez N, Hsu CD. Disorders of placental villous maturation are present in one-third of cases with spontaneous preterm labor. Journal of Perinatal Medicine, (ahead of print) 2021. https://doi.org/10.1515/jpm-2020-0138
Pacora P, Romero R, Jung E, Gudicha DW, Hernandez-Andrade E, Musilova I, Kacerovsky M, Jaiman S, Erez O, Hsu CD, Tarca AL. Reduced fetal growth velocity precedes antepartum fetal death. Ultrasound Obstet Gynecol. 2020 Sep 16. doi: 10.1002/uog.23111. Epub ahead of print. PMID: 32936481.
Jaiman S, Romero R, Pacora P, Jung EJ, Kacerovsky M, Bhatti G, Yeo L, Hsu CD. Placental delayed villous maturation is associated with evidence of chronic fetal hypoxia. J Perinat Med. 2020 Jun 25;48(5):516-518. PMID: 32396141; PMCID: PMC7351034.
Jaiman S, Romero R, Pacora P, Jung E, Bhatti G, Yeo L, Kim YM, Kim B, Kim CJ, Kim JS, Qureshi F, Jacques SM, Erez O, Gomez-Lopez N, Hsu CD. Disorders of placental villous maturation in fetal death. J Perinat Med. 2020 Apr 1; PMID: 32238609.
Tarca AL, Romero R, Pique-Regi R, Pacora P, Done B, Kacerovsky M, Bhatti G, Jaiman S, Hassan SS, Hsu CD, Gomez-Lopez N. Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy. BMC Med Genomics. 2020 Feb 12;13(1):25. PubMed PMID: 32050959.
Pacora P, Romero R, Jaiman S, Erez O, Bhatti G, Panaitescu B, Benshalom-Tirosh N, Jung EJ, Hsu CD, Hassan SS, Yeo L, Kadar N. Mechanisms of death in structurally normal stillbirths. J Perinat Med. 2019 Feb 25;47(2):222-240. doi: 10.1515/jpm-2018-0216. PubMed PMID: 30231013; PubMed Central PMCID: PMC6349478.
Romero R, Kim YM, Pacora P, Kim CJ, Benshalom-Tirosh N, Jaiman S, Bhatti G, Kim JS, Qureshi F, Jacques SM, Jung EJ, Yeo L, Panaitescu B, Maymon E, Hassan SS, Hsu CD, Erez O. The frequency and type of placental histologic lesions in term pregnancies with normal outcome. J Perinat Med. 2018 Aug 28;46(6):613-630. doi: 10.1515/jpm-2018-0055. PubMed PMID: 30044764; PubMed Central PMCID: PMC6174692
Jaiman S. Performing a perinatal autopsy. Journal of Fetal Medicine. September 2015, Volume 2, Issue 3, pp 101-111.
Jaiman S. Gross Examination of the Placenta and Its Importance in Evaluating an Unexplained Intrauterine Fetal Demise. Journal of Fetal Medicine. September 2015, Volume 2, Issue 3, pp 113-120.
Alhousseini A, Mahaseth M, Zeineddine S, Jaiman S, Berman S, Bryant D, Tan S, Hernandez-Andrade E. A Non-Lethal Osteogenesis Imperfecta Type II Mutation. Gynecol Obstet Invest. 2018 Nov 8:1-5. doi: 10.1159/000494491. [Epub ahead of print] PubMed PMID: 30408804
Alhousseini A, Jaiman S, Hernandez-Andrade E, Zeineddine S, Qureshi F, Jacques SM. Umbilical Artery Thrombosis with Associated Acute and Severe Fetal Growth Restriction and Transient Severe Protein S Deficiency: Report of a Case with Prenatal Ultrasound Diagnosis Allowing for Timely Intervention and Good Outcome. Case Rep Obstet Gynecol. 2018 Jul 9; 2018:6324362. doi: 10.1155/2018/6324362. eCollection 2018. PubMed PMID: 30112236; PubMed Central PMCID: PMC6077576
Kumar Vikraman S, Chandra V, Balakrishnan B, Jaiman S, Batra M, Kannoly G. Unguarded tricuspid orifice---a rare cause of fetal right atrial dilatation with characteristic color doppler sign: Case report with review of literature. J Clin Ultrasound. 2017 Jul 8;45(6):370-374. doi: 10.1002/jcu.22416. Epub 2016 Oct 18. Review. PubMed PMID: 27753109.
Jaiman S, Gundabattula SR, Ratha C. Familial Apple Peel Jejunal Atresia with Helical Umbilical Cord Ulcerations in Three Consecutive Pregnancies. Pediatr Dev Pathol. 2016 Jan-Feb;19(1):51-5. doi: 10.2350/15-04-1623-CR.1. Epub 2015 Jul 27. PubMed PMID: 26213797.
Jaiman S, Fernandez E, Gundabattula SR. Chorangioendothelioma of the Placenta: A Myth or Reality? Pediatr Dev Pathol. 2015 Sep-Oct;18(5):410-5. doi: 10.2350/14-11-1570-CR.1. Epub 2015 Apr 23. PubMed PMID: 25906437.
Pochiraju Manjula, Jaiman Sunil, and Gundabattula Sirisha Rao. Congenital Partial Atresia of the Fallopian Tube with Concomitant Ipsilateral Papilloma. Journal of Gynecologic Surgery. October 2014, 30(5): 314-317. doi:10.1089/gyn.2013.0114.
Jaiman S, Nalluri HB. Abnormal continuation of umbilical vein into extra-hepatic portal vein: Report of three cases. Congenit Anom (Kyoto). 2013 Dec;53(4):170-5. doi: 10.1111/cga.12020. PubMed PMID: 24712478.
Jaiman S, Nalluri H, Aziz N, Kolar G. Pallister-Hall syndrome presenting as an intrauterine fetal demise at 39 weeks' gestation. Indian J Pathol Microbiol. 2012 Jan-Mar;55(1):100-3. doi: 10.4103/0377-4929.94873. PubMed PMID: 22499313.
Jaiman S, Ulhøj BP. Bilateral intravesical ureterocele associated with unilateral partial duplication of the ureter and other anomalies: proposal of a new variant to the classification of ureteroceles based on a perinatal autopsy, review of the literature and embryology. APMIS. 2010 Oct;118(10):809-14. doi: 10.1111/j.1600-0463.2010.02666. x. Epub 2010 Aug 17. PubMed PMID: 20854476.
Jaiman S, Johansen T. Eosinophilic/T-cell chorionic vasculitis and intrauterine fetal demise at 34 weeks: case report and review of the literature. Pediatr Dev Pathol. 2010 Sep-Oct;13(5):393-6. doi: 10.2350/09-04-0646-CR.1. Epub 2009 Oct 19. Review. PubMed PMID: 19863447.