SIDDHESH ARAS, M.B.B.S., PH.D. ACADEMIC AFFILIATIONS Assistant Professor (Research) Center for Molecular Medicine and Genetics Wayne State University School of Medicine EDUCATION & TRAINING B.B.S, Grant Medical College, University of Mumbai, India (2001) Residency, Clinical Microbiology, Grant Medical College, Sir JJ Group of Hospitals, Mumbai, India (2004) D., Microbiology, Immunology and Parasitology, LSU Health Sciences Center, New Orleans, LA (2010) Post-doctoral Fellow, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI (2014) RESEARCH ACCOMPLISHMENTS Discovery of a novel mechanism of transcriptional activation by Epstein-Barr Nuclear Antigen 1. Characterization of a novel HIF-independent oxygen responsive element activated under conditions of moderate experimental hypoxia. Characterization of a novel cellular stress responsive protein, MNRR1 (Mitochondrial-Nuclear Retrograde Regulator 1). RESEARCH INTERESTS Mitochondrial disease Host cell bioenergetic regulation in response to inflammation Role of mitochondria in neurodegeneration and cancer SELECT PUBLICATIONS Aras S, Maroun MC, Song Y, Bandyopadhyay S, Stark A, Yang ZQ, Long MP, Grossman LI, Fernández-Madrid F. Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis. BMC Cancer. 2019 May 2; 19:411. PMID: 31046734 Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI. MNRR1 (formerly CHCHD2) is a bi- organellar regulator of mitochondrial metabolism. Mitochondrion. 2015 Jan; 20:43-51. PMID: 25315652 Aras S, Singh G, Johnston K, Foster T, Aiyar A. Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009 Jun; 5:e1000469. PMID: 19521517 COURSES Special topics in cancer metabolism (CB7300/7240) – Cancer Bioenergetics